D4.1 Catalogue of RWE relevant AD models and simplistic disease stage framework

This deliverable provides an inventory of existing disease progression models for mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. Based on a systematic literature review, a total of 40 disease progression models were identified. For each model, contextual information (including data sources and size, disease stage, population characteristics, etc.), model outcome, and input variables required by the model were extracted. Additionally, three unpublished models developed by the EFPIA Consortium members were reviewed and described in a similar manner.